Angiotensin II human ( Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe )

Catalog No. M14532 CAS No. 4474-91-3

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Product Name

Angiotensin II human
Note

Research use only, not for human use.
Brief Description

Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE).
Description

Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity.
Synonyms

Angiotensin II; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe
Pathway

Endocrinology/Hormones
Target

RAAS
Recptor

AT receptor
Research Area

Cardiovascular Disease
Indication

——

CAS Number

4474-91-3
Formula Weight

1046.18
Molecular Formula

C50H71N13O12
Purity

>98%(HPLC)
Solubility

H2O: ≥ 50 mg/mL
SMILES

O=C(O)C[C@H](N)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CN=CN2)C(N3[C@H](C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)CCC3)=O)=O)=O)=O)=O)=O
Chemical Name

(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-5-yl)methyl)-17-amino-5-((S)-sec-butyl)-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-((diaminomethylene)amino)propyl)-8-(4-hydroxybenzyl)-11-isopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid

1.de Gasparo M, et al. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000 Sep;52(3):415-72.

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